Pain Relief: Marijuana vs. Opioids

Marijuana vs Opioids
Marijuana has been used for pain management in medical traditions globally, and modern scientific research supports its effectiveness. With the ongoing opioid crisis, there's growing interest in medical marijuana as an alternative for pain management. Studies reveal that over 40% of respondents who used both marijuana and opioids reported a decrease or cessation in their opioid use when marijuana was also used, citing better pain management, fewer side effects, lack of withdrawal symptoms, and lower cost as reasons for the switch. Furthermore, research indicates that the legalization of medical marijuana may reduce opioid reliance, with many patients reporting a preference for cannabis over opioids for pain relief.
Table of Contents

Marijuana has long been used for pain in medical traditions around the world. Today, both patient experience and modern scientific research support claims of medical marijuana’s effectiveness for pain management. It is also known that marijuana targets the body’s pain receptors in ways similar to synthetic opioids.

And so, in light of America’s ongoing struggle with a sweeping opioid crisis of addiction and overdose deaths, it makes sense that there is a growing interest both among the public and the medical community in the possibilities of medical marijuana as an alternative to pharmaceuticals for pain management.

In the past, CannaMD has reported on this trend, which includes a number of high-profile celebrities and athletes. Now, scientific studies put hard numbers to the trend and reveal some interesting and encouraging outcomes that take place when medical marijuana is substituted for opioids.

Using Cannabis to Quit Opioids

In the fall of 2018, scientists at the San Francisco Veterans Affairs Medical Center released findings from a survey on the subject of marijuana versus opioids. The researchers looked at the results of a nationally representative study of more than 9,000 respondents who shared information on their use of opioids and marijuana.

Questions included any changes in personal levels of opioid use when marijuana was also used, and the reasons why patients were substituting marijuana for prescription pain medications. Of the respondents who reported using marijuana and opioids, over 4 in 10 said they had decreased or stopped their use of opioids when marijuana was also used.

Among the most common reasons patients cited for moving to marijuana were:

  • Better pain management
  • Fewer side effects
  • Lack of withdrawal symptoms
  • Lower cost

As is often the case in the academic community, the study authors noted that more research on the subject was needed, but also add that:

Our findings suggest that even if objective measures do not support that marijuana is substitutive for opioid use, patients perceive that marijuana use has reduced their opioid use. Perhaps the commercialization of marijuana and the favorable media coverage surrounding the health effects of marijuana are fostering such a perception.

Marijuana Preferred Over Pain Pills

A broad-based study conducted by Florida International University looked at information from the National Survey on Drug Use and Health. The study, which surveyed more than 120,000 individuals, sought to determine whether those who lived in states where medical marijuana was legal were less likely or more likely to turn to opioids for pain relief.

The authors report that the legalization of medical marijuana:

May be effective at reducing opioid reliance as survey respondents living in states with medical cannabis legislation are much less apt to report using opioid analgesics than people living in states without such laws, net other factors.

Results further indicate that the presence of medicinal cannabis legislation appears to have no influence over opioid misuse.

This led to the conclusion that:

Medical marijuana laws may ultimately serve to attenuate the consequences of opioid over reliance.

Other takeaways from this study include findings that:

  • Cannabis enabled patients to reduce their reliance on opioids
  • A significant number of respondents felt cannabis was equal to opioids for pain relief
  • Many patients preferred cannabis over opioids

Opioid Prescriptions Likely to Decline

As more people gain access to medical marijuana, dependence on opioids for pain relief is likely to decline. This was the conclusion of a report jointly published by researchers at the University of Alabama and Vanderbilt University, which looked at trends based on more than 1.3 billion opioid prescriptions written between 2011 and 2018. The purpose of this study was to investigate potential links between opioid use and changes in medical marijuana laws.

The authors state:

We find that recreational and medical cannabis access laws reduce the number of morphine milligram equivalents prescribed each year by 6.9 and 6.1 percent, respectively.

These laws also reduce the total days supply of opioids prescribed, the total number of patients receiving opioids, and the probability a provider prescribes any opioids net of any offsetting effects.

Additionally, we find consistent evidence that cannabis access laws have different effects across types of providers and physician specialties.

In addition, data from the 2017 National Survey on Drug Use and Health showed a potential inverse relationship between marijuana and opioid use, based on data that reported a drop of opioid misuse from 2016 to 2017 (from 11.8 million to 11.4 million individuals), while marijuana use increased over the same period (from 24 million to 26 million individuals).

Severe Pain: Marijuana Vs. Opioids

Some of the more interesting data on the relationship between opioids and medical marijuana for pain management comes from the field of orthopedic surgery. A study of more than 500 pre-operative patients suffering from acute arthritis pain showed that marijuana use had increased from 9 to 15 percent between 2012 and 2017, while opioid use decreased from 24 percent to 17 percent over the same time period.

Another finding of the study was that there was minimal crossover between these treatment options, with only three percent of respondents using both marijuana and opioids.

More insights come from a survey of patients who underwent total joint replacement surgery. Those who received the cannabinoid medication Dronabinol had shorter lengths of stay and consumed fewer opioids.

Study author, Thomas R. Hickernell, MD, states:

There is a growing body of anecdotal and circumstantial evidence that cannabinoids, or compounds derived from cannabis plants, may play a role in mitigating some of the harms of the opioid epidemic.

A similar clinical trial study proposal of post-operative patients recovering from total knee replacements notes:

While opioids are effective to manage the pain, they can have acute and chronic complications, including confusion, nausea, vomiting, constipation and high risk of addiction.

Medical cannabis is an effective and safe alternative for pain treatment.

Recent studies showed that patients have reported a reduction in opioid usage when taking cannabis as a substitute for pain relief.

More Information

To learn more about medical marijuana and pain management, see:

How Does Medical Marijuana Help Pain?

Marijuana and Cancer Pain

Marijuana and Arthritis: The Basics

Fibromyalgia Success with Cannabis

Pain Pills Controversy: Celebrities Choose Cannabis

Harvard Professor’s Thoughts on Marijuana and Pain

Updated: July 27, 2023

Article Written By:

Pierce Hoover

Pierce Hoover is a career journalist with more than three decades of experience in print, broadcast and online writing, editing and reporting, with more than 5,000 articles published in national and international print media and online. His focus on medical marijuana therapies mirrors his broader interest in science-based alternative medical practices.


Questions about medical marijuana? Ready to get your card and purchase legal cannabis products? CannaMD‘s state-certified network of medical marijuana doctors are here to help! Contact CannaMD‘s experienced team at (855) 420-9170 today. You can also find out if you qualify for medical marijuana treatment with our quick online application!

Find Out If You Qualify

You may be eligible for medical marijuana!

To stay up-to-date with the latest studies and legal regulations surrounding medical marijuana treatment, be sure to follow CannaMD on Facebook and sign up for our newsletter, below!

Join 100k+ Subscribers!

Get updates on more posts like this!

Related PostS

Feedback from our readers is very important and helps us provide quality articles. Please don’t be shy, leave a comment.

If you have a topic you would like us to cover in our blog or you are interested in writing guest posts please contact us for more information.

Get a medical marijuana certification in Florida