Marijuana May Work Better Than Migraine Medication

girl with a migraine
Medical marijuana is emerging as a promising alternative to traditional migraine medications, such as the FDA-approved Aimovig. Research indicates that marijuana not only prevents migraines but can also halt them in progress, reducing the number of migraine days per month. Despite the need for more clinical trials, preliminary findings suggest that medical marijuana could be as effective, if not more so, than Aimovig and other pharmaceutical treatments, with fewer side effects and at a lower cost. This development offers hope to the millions of U.S. adults who experience chronic daily migraines and are seeking effective treatment options.
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The medical world is buzzing with the FDA’s recent approval of migraine medication Aimovig, the first CGRP receptor blocker designed to prevent migraines. However, research suggests a different treatment may hold more promise.

Migraines and Aimovig

Far more serious than a headache, migraines are a neurological disease listed as the sixth most disabling illness in the world. Every ten seconds, someone in the U.S. goes to the emergency room complaining of head pain; approximately 1.2 million visits are from acute migraine attacks.

Aimovig’s appeal rests largely on its claim to stop migraines before they start. Three clinical trials have demonstrated it works: Over the course of three to six months, Aimovig-treated patients experienced, on average, one to two fewer monthly migraine days than those on placebo.

The downside? Treatment comes in an auto-injector device (like an EpiPen) and has possible side-effects, including: pain at the injection site and constipation.

As Harvard neurologist Elizabeth Loder noted prior to launch, “It’ll be a shame if the price for erenumab [Aimovig] does not reflect its modest efficacy.”

On May 17, Aimovig announced its price:

$575 a month.

Hope for patients

A closer look at Aimovig’s data reveals that, before adjusting for placebo comparison, participants experienced an average of 2.9 to 6.6 less migraine days a month (depending on study, length, and dosage). Not mentioned? A separate study suggesting that a different medication may be able to achieve the same results, with less risk of serious side effects, for less than half the price.

The treatment?

Medical marijuana.

In 2016, Pharmacotherapy published results of a retrospective chart review analyzing medical marijuana use in 121 migraine patients. The study showed marijuana successfully prevented migraines; patients who used marijuana experienced 5.8 less migraine days a month.  Moreover, patients also reported that marijuana stopped migraines in-progress.

These findings support a separate study presented at the Third Congress of the European Academy of Neurology which concluded:

“Cannabinoids are just as suitable as a [means of prevention] for migraine attacks as other pharmaceutical treatments.”

Lead study author Maria Nicolodi summarized:

“We were able to demonstrate that cannabinoids are an alternative to established treatments in migraine prevention.”

Could marijuana help your migraine?

Clinical trials are still needed; however, preliminary research suggests medical marijuana may be just as effective – if not more effective – at decreasing monthly migraine days as Aimovig and other pharmaceutical treatments.

Patients have also voiced strong support, with Vice columnist Caroline Thompson claiming:

“After 20 years and dozens of medications, I finally found something that helped.”

Unfortunately, more than four million U.S. adults experience chronic daily migraines. Research has shown that medication overuse is the prime reason episodic migraines turn chronic. With a number of arguments in its favor, this final point may just tip the scale for marijuana.

Summing up the state of current research, neuroscientist (and migraine sufferer) Michelle Ross explains:

“CBD [a marijuana compound] is really good for inflammation and pain. It’s crazy how many things it does.”

While state laws vary, CannaMD is proud to offer treatment to Florida patients suffering from a number of conditions that count migraines as a primary symptom (including cancer, PTSD, and epilepsy).

Updated: May 27, 2024

Jessica Walters

Jessica Walters serves as CannaMD's Chief Medical Researcher. Prior to her time at CannaMD, Jessica earned her degree from Harvard where she focused on neuropsychology. Her personal research interests include psychosocial interventions for obesity, depression, and generalized anxiety disorders.


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