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How to Reverse Marijuana Tolerance

Reverse MMJ Tolerance

Do you ever feel like you aren’t getting the full benefits from your medical cannabis therapy? You might be developing a tolerance for marijuana.

Research has shown that frequent cannabis use can reduce the body’s natural affinity for marijuana by desensitizing our natural cannabinoid receptors, which becomes less effective at binding with the cannabinoids found in marijuana. Fortunately, this effect is reversible, and can be accomplished with a number of simple practices that can naturally reset and boost your body’s affinity for cannabinoids and the other compounds in medical marijuana, such as terpenes.

Relax and Skip a Few Meals

The cannabinoid responsible for marijuana’s psychoactive effects, THC, is stored in fatty tissues. It’s been proven that taking a day off from eating can stimulate the release of this stored THC. The same studies show that boosting the release of adrenocorticotropic hormone (ACTH) can trigger a similar release. One of the best ways to encourage your body to increase ACTH production is to decrease your stress levels.

Get Moving

Another way to release THC stored in your fatty tissues is through exercise. A 2013 study showed that the release of THC stored in body fat can be increased by up to 15% by exercise, and will continue to be released for up to 28 days if you take a break from marijuana.

For more on marijuana and exercise, see:

Marijuana May Improve Exercise

Are Marijuana & Runner’s Highs the Same?

Seal It Up

If cannabis doesn’t seem to be working as well as it used to, it might not be you building up a tolerance. It might be the marijuana loosing strength. Research has confirmed that the way marijuana is stored can affect its potency.

Exposure to light has been shown to be the single greatest cause of degradation of THC content, and exposure to air is also bad, as it causes oxidation. That’s the same process that turns a piece of cut fruit brown when left out in the open. Storage temperature seems to be less important, but experts suggest that marijuana be stored in a sealed, lightproof container at room temperature to maintain its potency.

Take a Tolerance Break

The body’s natural affinity for marijuana can be boosted by reducing marijuana dosages, or taking a short break from marijuana-based medications all together. It has been shown that a two-day break from marijuana can result in a significant reversal in marijuana tolerance by resetting the ability of cannabinoid receptors to interact with the cannabinoids in marijuana. This effect continues to a lesser degree for up to 28 days.

You might not want to wait the full 28 days for a total reset, however. It has been pointed out that some degree of tolerance may be desirable, as it tends to mediate the psychoactive effects of THC while still providing the benefits of THC, CBD, and the many other cannabinoids found in marijuana.

Switch It Up

If you aren’t comfortable with completely pausing your marijuana therapy, consider changing your routine or methods of medication. As of yet, there hasn’t been much lab research on the benefits of changing dosages, products, or delivery methods to decrease marijuana tolerance, but there’s a lot of commentary from patients in the medical marijuana community to support this strategy.

One popular option is to switch strains. Another is to try new methods of uptake, perhaps switching to tincture oils or trying a vaping or dabbing device. There’s some buzz on the Internet over the strategy of eating mangoes to increase the uptake of myrcene, which in turn boosts the body’s affinity for THC. As of yet, there’s not much hard science supporting this popular notion, but it might be worth giving it a try. Other myrcene-boosting foods include broccoli and nuts. So at the very least, you’ll be enjoying a healthful diet to complement your medical marijuana therapies!

To learn more about dietary influences on marijuana potency, see:

Foods That Increase Marijuana’s Effects

Get Your Medical Marijuana Card

If you have questions about medical marijuana, we can help! CannaMD has a team of certified medical marijuana doctors who are prepared to answer any questions you might have! You can reach us at (855) 420-9170.  You can also find out if you qualify for medical marijuana with our quick online application.

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  1. I tried cannabis last year for my many conditions from a work accident which left me with 32 broken bones including my spine which left me totally disabled after a very history with opiates which left me addicted I went to Colorado to try medical marijuana after just one day I was able to reduce my pain meds 70% the next day I went back to the dispensary and tried some other varieties as the bud tender recommended I try I had the best two weeks of my 30 yrs of chronic pain I strongly recommend medical cannabis for all chronic pain patients sincerely Nick Lovero😊

    1. We’re so sorry to hear about your accident, but happy that medical cannabis has been able to help! Please let us know if there’s ever anything we can do to assist. Wishing you continued health and wellness!

  2. This is fine, but I am also interested in getting more psychoactive effects from THC. I find I am not getting very high and I prefer to get very high. I buy wax that has at least 80% THC and I vape that. But I am getting frustrated as I find I must take more and more hits to get high. And yes I do use it for pain but I am also using it for the high. I wouldn’t call that recreational, although it is perfectly legal to use it for recreational purposes in my state (Washington) and I see absolutely wrong with that…it is safer, less addictive than booze. But all you ever talk about is Medicinal when many WANT to get high. I have a lot of very serious pain and I still use it for both. I won’t buy CBD only stuff, infact CBD is not necessary for pain relief. I buy high 80-90% THC and 0% CBD and it works great for pain. And it is way cheaper to vape wax from a globe than to buy the stupid cartridges that are way over priced.

  3. I have taken fish oil suppliments and that helps a LOT, I cant belive this was not mentioned here…

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