Marijuana Guidelines: How to Treat Anxiety

Marijuana Guidelines Anxiety
Anxiety, a common human emotion, becomes a serious condition known as generalized anxiety disorder for over 40 million Americans. Traditional treatments often involve pharmaceutical antidepressants like selective serotonin reuptake inhibitors (SSRIs), but their effectiveness is questionable, and they come with undesirable side effects. Research suggests that marijuana, specifically a combination of high CBD and high THC, is a viable alternative for treating anxiety, with patients reporting significant reduction in anxiety levels. Interestingly, the study found that two puffs of inhaled cannabis were enough to provide relief, with no additional reduction in anxiety with more puffs.
Table of Contents

Anxiety is a familiar human emotion. You probably felt anxious before that big test back in high school, and you’ll probably experience a bit of anxiety when contemplating major life events. That’s normal. But for more than 40 million Americans, anxiety is not a passing thing. It’s a serious condition known as generalized anxiety disorder.

The National Institute of Mental Health defines generalized anxiety disorder as “having excessive anxiety or worry, most days for at least six months, about a number of things such as personal health, work, social interactions, and everyday routine life circumstances.” These pervasive fears and anxieties can cause significant problems in many areas of the sufferer’s life.

Recognizing Anxiety Disorders

Generalized anxiety disorder symptoms typically include:

  • Feeling restless, wound-up, or on-edge
  • Being easily fatigued
  • Having difficulty concentrating (“mind going blank”)
  • Being irritable
  • Having muscle tension
  • Difficulty controlling feelings of worry
  • Having sleep problems, such as difficulty falling or staying asleep, restlessness, or unsatisfying sleep

Note: Symptoms may vary among patients.

Conventional Treatments Often Fall Short

In mainstream medicine, the most common treatment for anxiety disorders is the prescription of pharmaceutical antidepressants known as selective serotonin reuptake inhibitors (SSRIs). Just over one in ten Americans over the age of 12 take these medications. You may recognize some of the more common drugs in this category such as Prozac, Celexa, Zoloft, Paxil, and Lexapro.

Yet despite a four-fold increase in the use of these drugs over the past three decades, the medical community has not seen a decrease in mental health issues such as generalized anxiety disorder. Instead, disability rates due to mental health have actually doubled. These numbers have caused some leaders in the field of mental health to question the effectiveness of pharmaceutical medications for the treatment of anxiety and other disorders.

And on top of SSRIs mixed record for effectiveness in real-world situations, these drugs have a number of undesirable side effects, ranging from headaches, dizziness and nausea to tremors, insomnia and a decreased sex drive.

Wouldn’t it be nice to have a natural alternative to treat anxiety?

Marijuana And Anxiety

Anecdotal evidence and patient experiences have long suggested that medical cannabis may reduce anxiety and alleviate stress. But statistically relevant research on the anxiety-reducing effects of marijuana has long remained sparse.

Early evidence comes from a pair of double-blind, placebo-controlled studies conducted in 1993 and 2011, which indicate that oral cannabidiol (CBD) – a chemical compound found in marijuana – significantly reduced anxiety and discomfort during a simulated public speaking task, both for students described as “normal” and in-patients diagnosed with social anxiety disorder.

More recent and comprehensive evidence comes from a study conducted by researchers from Washington State University.

A portion of this study focused on the effect that inhaled cannabis had on the perceived reduction of anxiety levels among 770 medical marijuana users (363 men, 402 women). Each study participant self-administered medical cannabis via one of five inhalation methods (smoking, vaping, concentrates, dab bubber, dab portable), and reported their results via the app Strainprint.

Based on the analysis of 5,085 reported sessions, the authors of the study concluded that:

  • In 93 % of all cases, medical marijuana users perceived a reduction in anxiety and stress levels following cannabis use
  • Among both men and women, symptoms of anxiety and stress were reduced by an average of 58 %

These numbers suggest that cannabis is a viable alternative to traditional SSRI pharmaceutical options, and also lacks the numerous potential side effects that these drugs may cause.

(More information on the relationship between anxiety and the use of medical marijuana can be found in our blog: Anxiety and Marijuana, What Science Says.)

Good News For Women With Anxiety Disorders

One specific goal of the study was to “examine potential gender differences in the perceived efficacy of cannabis in reducing symptoms of anxiety.” Or, in simpler terms: To determine if there might there be differences between men and women in the level of anxiety reduction achieved when using medical marijuana. This question was considered relevant because women are 60 % more likely than men to suffer from anxiety disorders.

The study revealed that while men and women both reported significant reductions in anxiety after inhaling medical cannabis, women experienced a greater degree of relief.

Using a scale of one to ten to describe their anxiety levels, women in the study were able to reduce symptoms from a average level of around six to levels just below two. The men’s average relief for the same starting average point of six was reduced to a level of approximately three.


Reactions to the use of medical cannabis are subject to variables including the frequency of dose and the ratio of marijuana’s two active ingredients, tetrahydrocannabinol (THC) and cannabidiol (CBD). The Washington State University study sought to determine the most favorable balance of these two compounds for the treatment of conditions including anxiety disorder, stress and depression.

Based on patient reporting, it was determined that a combination of high CBD (greater than 11 %) and high THC (greater than 26 %) was most effective for the treatment of anxiety. This combination was also shown to be effective for reducing stress.

Two Puffs May Be Enough

An additional variable tracked by the study was the relationship of dose to relief, with dose defined as the number of inhalations, from one to ten. Analysis of the results showed that:

One puff produced significantly smaller changes in ratings of anxiety than all other doses (2 to 10+), but no other differences across doses beyond one puff were detected.

In other words, the data indicates that two puffs are better than one, but that there is no additional reduction in anxiety with additional puffs. This information may prove valuable for patients seeking relief from anxiety without the potential intoxicating effects of additional puffs.

In conclusion, the Washington State University study stated that:

Results from the present study indicate that medical cannabis users report a substantial and significant reduction in symptoms of negative affect shortly after using cannabis.

This is good news for the millions who suffer from anxiety disorders, and are seeking a natural alternative to pharmaceuticals.

Updated: May 24, 2024

Article Written By:

Pierce Hoover

Pierce Hoover is a career journalist with more than three decades of experience in print, broadcast and online writing, editing and reporting, with more than 5,000 articles published in national and international print media and online. His focus on medical marijuana therapies mirrors his broader interest in science-based alternative medical practices.


Questions about medical marijuana? Ready to get your card and purchase legal cannabis products? CannaMD‘s state-certified network of medical marijuana doctors are here to help! Contact CannaMD‘s experienced team at (855) 420-9170 today. You can also find out if you qualify for medical marijuana treatment with our quick online application!

Find Out If You Qualify

You may be eligible for medical marijuana!

To stay up-to-date with the latest studies and legal regulations surrounding medical marijuana treatment, be sure to follow CannaMD on Facebook and sign up for our newsletter, below!

Join 100k+ Subscribers!

Get updates on more posts like this!

Related PostS

Feedback from our readers is very important and helps us provide quality articles. Please don’t be shy, leave a comment.

If you have a topic you would like us to cover in our blog or you are interested in writing guest posts please contact us for more information.

Get a medical marijuana certification